Dechra Carprofen Nsaids Pain Relief Tablet Beef Flavor for Dogs (20mg)
This is a prescription medicine. A prescription is required from your veterinarian before we can supply this product. Please ensure that you have read the "How to Order" page before ordering this item.
Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of inflammation and to provide analgesia. Carprofen appears to have greater activity against the cyclooxygenase-2 (COX-2) isoenzyme than COX-1, which may partly explain why carprofen appears to be less ulcerogenic than many other NSAIDs.Pharmacokinetics There is good absorption from the gastrointestinal tract following oral administration. There is a high degree of protein binding and a small volume of distribution that is mostly to extracellular sites. Carprofen is a weak acid, so it readily penetrates into inflamed tissue. Elimination is usually following metabolism by hepatic enzymes, and the less active metabolites are eliminated via a combination of faecal and urinary excretion. Urinary excretion of the unchanged drug is minimal, and relies on glomerular filtration and tubular excretion. There is also a degree of hepatic excretion and evidence of enterohepatic recycling.
2mg/kg to 4 mg/kg bodyweight/day. Dose, frequency and duration of treatment will depend on clinical response to treatment. Initial therapy at 4 mg/kg bodyweight/day given in two equally divided doses is generally recommended. Subject to clinical response, the dose may be reduced to 2 mg/kg bodyweight/day administered as a once daily dose. All dogs should undergo a thorough clinical examination and appropriate laboratory tests before introduction of NSAID therapy. During extended administration, appropriate re-evaluation and laboratory tests should be undertaken periodically.
Active Ingredient : carprofen 20mg
Pack Size : As per prescription