Dechra Carprofen Nsaids Pain Relief Tablet for Dogs (20mg)
This is a prescription medicine. A prescription is required from your veterinarian before we can supply this product. Please ensure that you have read the "How to Order" page before ordering this item. The original, physical copy of the accompanying prescription will be collected upon delivery.
Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of inflammation and to provide analgesia. Carprofen appears to have greater activity against the cyclooxygenase-2 (COX-2) isoenzyme than COX-1, which may partly explain why carprofen appears to be less ulcerogenic than many other NSAIDs.Pharmacokinetics There is good absorption from the gastrointestinal tract following oral administration. There is a high degree of protein binding and a small volume of distribution that is mostly to extracellular sites. Carprofen is a weak acid, so it readily penetrates into inflamed tissue. Elimination is usually following metabolism by hepatic enzymes, and the less active metabolites are eliminated via a combination of faecal and urinary excretion. Urinary excretion of the unchanged drug is minimal, and relies on glomerular filtration and tubular excretion. There is also a degree of hepatic excretion and evidence of enterohepatic recycling.
2mg/kg to 4 mg/kg bodyweight/day. Dose, frequency and duration of treatment will depend on clinical response to treatment. Initial therapy at 4 mg/kg bodyweight/day given in two equally divided doses is generally recommended. Subject to clinical response, the dose may be reduced to 2 mg/kg bodyweight/day administered as a once daily dose. All dogs should undergo a thorough clinical examination and appropriate laboratory tests before introduction of NSAID therapy. During extended administration, appropriate re-evaluation and laboratory tests should be undertaken periodically.
Active Ingredient : carprofen 20mg
Package Size : Dispensed according to prescription