Elanco Fortekor Cardiovascular Treatment for Dogs Cats 20mg
This is a prescription medicine. A prescription is required from your veterinarian before we can supply this product. Please ensure that you have read the "How to Order" page before ordering this item. The original, physical copy of the accompanying prescription will be collected upon delivery.
Fortekor Tablets are used in the treatment of mild, moderate, and severe congestive heart failure in dogs and chronic renal insufficiency in cats. For dogs, Fortekor lowers the blood pressure and loading pressure on the heart by reducing the constriction of both arteries and the veins.
Pharmacology Benazepril hydrochloride, a pro-drug, is hydrolysed in vivo to benazeprilat, which inhibits angiotensin converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I into active angiotensin II. Fortekor reduces local and systemic effects mediated by angiotensin II, including vasoconstriction of arteries and veins, and retention of sodium and water by the kidney. Fortekor causes long lasting inhibition of plasma ACE in dogs and cats, with significant inhibition persisting for 24 hours after a single dose.
FORTEKOR is well tolerated in the target species. In normal cats treated with 10 and 20 mg/kg/day for one year, the only clinically relevant findings were increased urine volume and pH in male cats at 10 and 20 mg/kg, increased urine volume in females at 20 mg/kg/day, and decreased urine specific gravity in both male and female cats at 10 and 20 mg/kg/day, as compared to control animals. Trace to mild hypertrophy/hyperplasia of the juxtaglomerular cells was noted on histopathology in cats receiving 10 and 20 mg/kg/day. The clinical relevance of these changes is unknown.
Pregnancy, lactation. The safety of Fortekor has not been tested in breeding animals. Fortekor is therefore not recommended for use in pregnant or lactating animals. Fortekor should therefore be used only if justified clinically, considering the risk–benefit ratio.Clinical trials have shown Fortekor to have good renal tolerance. No evidence of renal toxicity of Fortekor has been observed in normal dogs and cats during clinical trials. The biliary excretion of benazeprilat means that there is little risk of bioaccumulation in dogs and cats with impaired renal function. In cats, plasma creatinine concentrations may continue to increase at the start of therapy. This effect is related to the therapeutic effect of the product in reducing glomerular capillary blood pressure and therefore it is not necessarily a reason to stop therapy in the absence of other signs. First Aid If poisoning occurs, contact a vet.
Active Ingredients :
Each tablet contains 20mg benazepril hydrochloride.
Dispensed according to prescription.